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Total Synthesis of (±)-Mitorubrinic Acid

(±)-Mitorubrinic acid, a member of the azaphilone family of natural products, has been constructed in 12 steps. Key aspects of the synthesis include elaboration and oxidative dearomatization of an isocoumarin intermediate to provide the azaphilone nucleus with a disubstituted, unsaturated carboxylic...

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Detalhes bibliográficos
Main Authors: Marsini, Maurice A., Gowin, Kristoffer M., Pettus, Thomas R. R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2440338/
https://ncbi.nlm.nih.gov/pubmed/16869640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/o10610993
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