Predicting drug-induced changes in QT interval and arrhythmias: QT-shortening drugs point to gaps in the ICHS7B Guidelines

BACKGROUND AND PURPOSE: The regulatory guidelines (ICHS7B) recommending inhibition of the delayed rectifier K(+) current (I(Kr)), carried by human ether-a-go-go-related gene (hERG) channels in cardiac cells (the hERG test), as a ‘first line' test for identifying compounds inducing QT prolongati...

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Detalhes bibliográficos
Main Authors: Lu, H R, Vlaminckx, E, Hermans, A N, Rohrbacher, J, Van Ammel, K, Towart, R, Pugsley, M, Gallacher, D J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2440085/
https://ncbi.nlm.nih.gov/pubmed/18493243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.191
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