Vardenafil, but not sildenafil or tadalafil, has calcium-channel blocking activity in rabbit isolated pulmonary artery and human washed platelets

BACKGROUND AND PURPOSE: Phosphodiesterase type-5 (PDE5) inhibitors constitute a novel and important therapeutic option for the treatment of pulmonary hypertension. The effects of the PDE5 inhibitors sildenafil, tadalafil and vardenafil on rabbit isolated pulmonary artery ring preparations and on int...

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Detalhes bibliográficos
Main Authors: Toque, H A, Teixeira, C E, Priviero, F B M, Morganti, R P, Antunes, E, De Nucci, G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2439847/
https://ncbi.nlm.nih.gov/pubmed/18536732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.141
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