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The associative nature of adenylyl transfer catalyzed by T4 DNA ligase
DNA ligase seals nicks in dsDNA using chemical energy of the phosphoanhydride bond in ATP or NAD(+) and assistance of a divalent metal cofactor Mg(2+). Molecular details of ligase catalysis are essential for understanding the mechanism of metal-promoted phosphoryl transfer reactions in the living ce...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2438423/ https://ncbi.nlm.nih.gov/pubmed/18562298 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709140105 |
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