The associative nature of adenylyl transfer catalyzed by T4 DNA ligase

DNA ligase seals nicks in dsDNA using chemical energy of the phosphoanhydride bond in ATP or NAD(+) and assistance of a divalent metal cofactor Mg(2+). Molecular details of ligase catalysis are essential for understanding the mechanism of metal-promoted phosphoryl transfer reactions in the living ce...

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Detalhes bibliográficos
Main Authors: Cherepanov, Alexey V., Doroshenko, Elena V., Matysik, Jörg, de Vries, Simon, de Groot, Huub J. M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2438423/
https://ncbi.nlm.nih.gov/pubmed/18562298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709140105
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