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Ablation of thymic export causes accelerated decay of naïve CD4 T cells in the periphery because of activation by environmental antigen
A model of chemical thymectomy by inducible Rag ablation was used to study peripheral T cell homeostasis. Induction of Rag ablation was efficient and complete, leading to cessation of thymic T cell production within 3–4 weeks. The decay of peripheral T cells became apparent with a delay of an additi...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2438401/ https://ncbi.nlm.nih.gov/pubmed/18562288 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803732105 |
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