Modification of the Primary Tumor Microenvironment by Transforming Growth Factor α-Epidermal Growth Factor Receptor Signaling Promotes Metastasis in an Orthotopic Colon Cancer Model

The transforming growth factor α (TGFα)/epidermal growth factor receptor (EGFR) signaling pathway appears to play a critical role in colon cancer progression, but the cellular and molecular mechanisms that contribute to metastasis remain unknown. KM12C colon cancer cell clones expressing high (C9) o...

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Detalhes bibliográficos
Main Authors: Sasaki, Takamitsu, Nakamura, Toru, Rebhun, Robert B., Cheng, Hua, Hale, Katherine Stemke, Tsan, Rachel Z., Fidler, Isaiah J., Langley, Robert R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2008
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2438298/
https://ncbi.nlm.nih.gov/pubmed/18583324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.071147
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