Enrichment of C-Terminal Fragments in TAR DNA-Binding Protein-43 Cytoplasmic Inclusions in Brain but not in Spinal Cord of Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis

TAR DNA-binding protein (TDP-43) has been recently described as a major pathological protein in both frontotemporal dementia with ubiquitin-positive inclusions (FTLD-U) and amyotrophic lateral sclerosis. However, little is known about the relative abundance and distribution of different pathological...

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Autors principals: Igaz, Lionel M., Kwong, Linda K., Xu, Yan, Truax, Adam C., Uryu, Kunihiro, Neumann, Manuela, Clark, Christopher M., Elman, Lauren B., Miller, Bruce L., Grossman, Murray, McCluskey, Leo F., Trojanowski, John Q., Lee, Virginia M.-Y.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2008
Matèries:
Regular Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2438296/
https://ncbi.nlm.nih.gov/pubmed/18535185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.080003
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