Activin B receptor ALK7 is a negative regulator of pancreatic β-cell function

All major cell types in pancreatic islets express the transforming growth factor (TGF)-β superfamily receptor ALK7, but the physiological function of this receptor has been unknown. Mutant mice lacking ALK7 showed normal pancreas organogenesis but developed an age-dependent syndrome involving progre...

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Hlavní autoři: Bertolino, Philippe, Holmberg, Rebecka, Reissmann, Eva, Andersson, Olov, Berggren, Per-Olof, Ibáñez, Carlos F.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2008
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2438235/
https://ncbi.nlm.nih.gov/pubmed/18480258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801285105
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