Confirmation of Single Exon Deletions in MLH1 and MSH2 Using Quantitative Polymerase Chain Reaction

Deletions of one or more exons in the mismatch repair genes MLH1 and MSH2 have been implicated in a significant fraction of hereditary nonpolyposis colorectal cancer (HNPCC or Lynch syndrome). Multiplex ligation-dependent probe amplification (MLPA) detection of deletions of multiple sequential exons...

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Bibliographische Detailangaben
Hauptverfasser: Vaughn, Cecily P., Lyon, Elaine, Samowitz, Wade S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2008
Schlagworte:
Regular Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2438205/
https://ncbi.nlm.nih.gov/pubmed/18556772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/jmoldx.2008.080021
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