Validation of Real-Time Methylation-Specific PCR to Determine O(6)-Methylguanine-DNA Methyltransferase Gene Promoter Methylation in Glioma

Epigenetic silencing of the DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) by promoter methylation predicts successful alkylating agent therapy, such as with temozolomide, in glioblastoma patients. Stratified therapy assignment of patients in prospective clinical trials according...

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Detalhes bibliográficos
Main Authors: Vlassenbroeck, Ilse, Califice, Stéphane, Diserens, Annie-Claire, Migliavacca, Eugenia, Straub, Josef, Di Stefano, Ivano, Moreau, Fabrice, Hamou, Marie-France, Renard, Isabelle, Delorenzi, Mauro, Flamion, Bruno, DiGuiseppi, James, Bierau, Katja, Hegi, Monika E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2008
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2438202/
https://ncbi.nlm.nih.gov/pubmed/18556773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/jmoldx.2008.070169
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