Uncoupling signal transducers from oncogenic MET mutants abrogates cell transformation and inhibits invasive growth

The assumption that genes encoding tyrosine kinase receptors could play a role in human cancers has been confirmed by the identification of oncogenic mutations in the kinase domain of RET and KIT. Recently, homologous residues were found mutated in MET, in papillary renal carcinomas (PRCs). The link...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Bardelli, Alberto, Longati, Paola, Gramaglia, Daniela, Basilico, Cristina, Tamagnone, Luca, Giordano, Silvia, Ballinari, Dario, Michieli, Paolo, Comoglio, Paolo M.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24381/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9826708/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.24.14379
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