Uncoupling signal transducers from oncogenic MET mutants abrogates cell transformation and inhibits invasive growth

The assumption that genes encoding tyrosine kinase receptors could play a role in human cancers has been confirmed by the identification of oncogenic mutations in the kinase domain of RET and KIT. Recently, homologous residues were found mutated in MET, in papillary renal carcinomas (PRCs). The link...

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Bibliografiska uppgifter
Huvudupphovsmän: Bardelli, Alberto, Longati, Paola, Gramaglia, Daniela, Basilico, Cristina, Tamagnone, Luca, Giordano, Silvia, Ballinari, Dario, Michieli, Paolo, Comoglio, Paolo M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The National Academy of Sciences 1998
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC24381/
https://ncbi.nlm.nih.gov/pubmed/9826708
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