Secretory PLA(2) inhibitor indoxam suppresses LDL modification and associated inflammatory responses in TNFα-stimulated human endothelial cells

BACKGROUND AND PURPOSE: Secretory phospholipase A(2) (sPLA(2)) is implicated in atherosclerosis, although the effects of specific sPLA(2) inhibitors have not been studied. We investigated the effects of the indole analogue indoxam on low-density lipoprotein (LDL) modification by sPLA(2) enzymes of d...

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Detalhes bibliográficos
Main Authors: Sonoki, K, Iwase, M, Sasaki, N, Ohdo, S, Higuchi, S, Takata, Y, Iida, M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2437901/
https://ncbi.nlm.nih.gov/pubmed/18264128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.12
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