Unmasking the functions of the chromaffin cell α(7) nicotinic receptor by using short pulses of acetylcholine and selective blockers

Methyllycaconitine (MLA), α-conotoxin ImI, and α-bungarotoxin inhibited the release of catecholamines triggered by brief pulses of acetylcholine (ACh) (100 μM, 5 s) applied to fast-superfused bovine adrenal chromaffin cells, with IC(50)s of 100 nM for MLA and 300 nM for α-conotoxin ImI and α-bungaro...

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Detalhes bibliográficos
Main Authors: López, Manuela G., Montiel, Carmen, Herrero, Carlos J., García-Palomero, Esther, Mayorgas, Inés, Hernández-Guijo, Jesús M., Villarroya, M., Olivares, Román, Gandía, Luis, McIntosh, J. Michael, Olivera, Baldomero M., García, Antonio G.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1998
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC24348/
https://ncbi.nlm.nih.gov/pubmed/9826675
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