Effect of CYP2C19*2 and *17 mutations on pharmacodynamics and kinetics of proton pump inhibitors in Caucasians

AIMS: To investigate the impact of CYP2C19 mutations *2-*6 and *17 on acid-inhibition and pharmacokinetics of lansoprazole (L15), omeprazole (O10, O20) and pantoprazole (P40) in Caucasians. METHODS: CYP2C19 genotyping for *2–*6 and *17 mutations was assessed in subjects who were H. pylori negative i...

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Main Authors: Hunfeld, Nicole G, Mathot, Ron A, Touw, Daan J, van Schaik, Ron H, Mulder, Paul G, Franck, Paul F, Kuipers, Ernst J, Geus, William P
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2008
Assuntos:
Pharmacogenetics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2432487/
https://ncbi.nlm.nih.gov/pubmed/18241283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2007.03094.x
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