The recovery time-course of CYP3A after induction by St John's wort administration

AIMS: To examine the recovery time course of CYP3A after enzyme induction by St John's wort administration. METHODS: The subjects were 12 healthy men, aged 20–33 years. On the first day, they received an oral dose of midazolam 5 mg without St John's wort (day −14). From the next day, they...

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Hlavní autoři: Imai, Hiromitsu, Kotegawa, Tsutomu, Tsutsumi, Kimiko, Morimoto, Takuya, Eshima, Nobuoki, Nakano, Shigeyuki, Ohashi, Kyoichi
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2008
Témata:
Drug Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2432480/
https://ncbi.nlm.nih.gov/pubmed/18294328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2008.03120.x
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