Drug interaction between St John's Wort and quazepam

AIM: St John's Wort (SJW) enhances CYP3A4 activity and decreases blood concentrations of CYP3A4 substrates. In this study, the effects of SJW on a benzodiazepine hypnotic, quazepam, which is metabolized by CYP3A4, were examined. METHODS: Thirteen healthy subjects took a single dose of quazepam...

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Detalhes bibliográficos
Main Authors: Kawaguchi, Atsuhiro, Ohmori, Masami, Tsuruoka, Shu-ichi, Nishiki, Kenta, Harada, Kenichi, Miyamori, Isamu, Yano, Ryo-ichi, Nakamura, Toshiaki, Masada, Mikio, Fujimura, Akio
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2004
Assuntos:
Drug Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884612/
https://ncbi.nlm.nih.gov/pubmed/15373933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2004.02171.x
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