Transfer of chloroquine and desethylchloroquine across the placenta and into milk in Melanesian mothers

AIMS: To investigate the transfer of chloroquine and its major bioactive metabolite desethylchloroquine across the placenta and into breast milk. METHODS: In Papua New Guinea, chloroquine (CQ; 25 mg base kg(−1)) is recommended for prophylaxis of malaria during pregnancy, and at the Alexishafen Healt...

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Hlavní autoři: Law, Irwin, Ilett, Kenneth F, Hackett, L Peter, Page-Sharp, Madhu, Baiwog, Francesca, Gomorrai, Servina, Mueller, Ivo, Karunajeewa, Harin A, Davis, Timothy M E
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2008
Témata:
Clinical Pharmacology in Pregnancy
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2432477/
https://ncbi.nlm.nih.gov/pubmed/18279478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2008.03111.x
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