Inhibition of placental P-glycoprotein: impact on indinavir transfer to the foetus

AIMS: To investigate the effect of P-gp inhibition on the maternal to foetal transfer of indinavir. METHODS: Term human placentae (n = 12) were from non-HIV infected women. Maternal to foetal transfer of indinavir was examined in the absence and presence of P-gp inhibitors PSC833 (n = 7) or ritonavi...

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Bibliografiske detaljer
Main Authors: Sudhakaran, Sreeja, Rayner, Craig R, Li, Jian, Kong, David C M, Gude, Neil M, Nation, Roger L
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2008
Fag:
Clinical Pharmacology in Pregnancy
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2432476/
https://ncbi.nlm.nih.gov/pubmed/18093255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2007.03067.x
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