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Blockade of Thrombospondin-1-CD47 Interactions Prevents Necrosis of Full Thickness Skin Grafts
Thrombospondin-1 is a potent physiologic regulator of nitric oxide driven blood flow and angiogenesis. This regulation requires the cell receptor CD47. In a murine model of skin graft survival we demonstrate that endogenous thrombospondin-1 limits graft survival via CD47 and targeting CD47 with anti...
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| Autores principales: | , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2432017/ https://ncbi.nlm.nih.gov/pubmed/18156939 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SLA.0b013e31815685dc |
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