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Evolution of the bile salt nuclear receptor FXR in vertebrates

Bile salts, the major end metabolites of cholesterol, vary significantly in structure across vertebrate species, suggesting that nuclear receptors binding these molecules may show adaptive evolutionary changes. We compared across species the bile salt specificity of the major transcriptional regulat...

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Hlavní autoři: Reschly, Erica J., Ai, Ni, Ekins, Sean, Welsh, William J., Hagey, Lee R., Hofmann, Alan F., Krasowski, Matthew D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2431107/
https://ncbi.nlm.nih.gov/pubmed/18362391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M800138-JLR200
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