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Evolution of the bile salt nuclear receptor FXR in vertebrates
Bile salts, the major end metabolites of cholesterol, vary significantly in structure across vertebrate species, suggesting that nuclear receptors binding these molecules may show adaptive evolutionary changes. We compared across species the bile salt specificity of the major transcriptional regulat...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2431107/ https://ncbi.nlm.nih.gov/pubmed/18362391 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M800138-JLR200 |
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