Hsp27 Inhibits Bax Activation and Apoptosis via a Phosphatidylinositol 3-Kinase-dependent Mechanism

Hsp27 inhibits mitochondrial injury and apoptosis in both normal and cancer cells by an unknown mechanism. To test the hypothesis that Hsp27 decreases apoptosis by inhibiting Bax, Hsp27 expression was manipulated in renal epithelial cells before transient metabolic stress, an insult that activates B...

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Detalhes bibliográficos
Main Authors: Havasi, Andrea, Li, Zhijian, Wang, Zhiyong, Martin, Jody L., Botla, Venugopal, Ruchalski, Kathleen, Schwartz, John H., Borkan, Steven C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2431006/
https://ncbi.nlm.nih.gov/pubmed/18299320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801291200
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