Notch-Deficient Skin Induces a Lethal Systemic B-Lymphoproliferative Disorder by Secreting TSLP, a Sentinel for Epidermal Integrity

Epidermal keratinocytes form a highly organized stratified epithelium and sustain a competent barrier function together with dermal and hematopoietic cells. The Notch signaling pathway is a critical regulator of epidermal integrity. Here, we show that keratinocyte-specific deletion of total Notch si...

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Detalhes bibliográficos
Main Authors: Demehri, Shadmehr, Liu, Zhenyi, Lee, Jonghyeob, Lin, Meei-Hua, Crosby, Seth D, Roberts, Christopher J, Grigsby, Perry W, Miner, Jeffrey H, Farr, Andrew G, Kopan, Raphael
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2430908/
https://ncbi.nlm.nih.gov/pubmed/18507503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0060123
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