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Extra centrosomes and/or chromosomes prolong mitosis in human cells: Control of mitotic duration

Using laser microsurgery and cell fusion we have explored how additional centrosomes and/or chromosomes influence the duration of mitosis in human cells. We find that doubling the chromosome number adds ∼10 minutes to a 20 minute division while doubling the number of centrosomes adds ∼30 minutes mor...

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Autors principals: Yang, Zhenye, Lončarek, Jadranka, Khodjakov, Alexey, Rieder, Conly L.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2430725/
https://ncbi.nlm.nih.gov/pubmed/18469805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1738
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