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Structural Analysis Reveals Conformational Plasticity in the Recognition of RNA 3′ Ends by the Human La Protein

The eukaryotic La protein recognizes the 3′ poly(U) sequences of nascent RNA polymerase III transcripts to assist folding and maturation. The 3′ ends of such RNAs are bound by the N-terminal domain of La (LaNTD). We have solved the crystal structures of four LaNTD:RNA complexes, each containing a di...

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Detalhes bibliográficos
Main Authors: Kotik-Kogan, Olga, Valentine, Elizabeth R., Sanfelice, Domenico, Conte, Maria R., Curry, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2430598/
https://ncbi.nlm.nih.gov/pubmed/18547518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2008.02.021
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