Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase–dependent DC functions and regulates experimental graft-versus-host disease in mice

Histone deacetylase (HDAC) inhibitors are antitumor agents that also have antiinflammatory properties. However, the mechanisms of their immunomodulatory functions are not known. We investigated the mechanisms of action of 2 HDAC inhibitors, suberoylanilide hydroxamic acid (SAHA) and ITF 2357, on mou...

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Detalhes bibliográficos
Main Authors: Reddy, Pavan, Sun, Yaping, Toubai, Tomomi, Duran-Struuck, Raimon, Clouthier, Shawn G., Weisiger, Elizabeth, Maeda, Yoshinobu, Tawara, Isao, Krijanovski, Oleg, Gatza, Erin, Liu, Chen, Malter, Chelsea, Mascagni, Paolo, Dinarello, Charles A., Ferrara, James L.M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2430497/
https://ncbi.nlm.nih.gov/pubmed/18568076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34712
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