Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase–dependent DC functions and regulates experimental graft-versus-host disease in mice

Histone deacetylase (HDAC) inhibitors are antitumor agents that also have antiinflammatory properties. However, the mechanisms of their immunomodulatory functions are not known. We investigated the mechanisms of action of 2 HDAC inhibitors, suberoylanilide hydroxamic acid (SAHA) and ITF 2357, on mou...

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Bibliografiske detaljer
Main Authors: Reddy, Pavan, Sun, Yaping, Toubai, Tomomi, Duran-Struuck, Raimon, Clouthier, Shawn G., Weisiger, Elizabeth, Maeda, Yoshinobu, Tawara, Isao, Krijanovski, Oleg, Gatza, Erin, Liu, Chen, Malter, Chelsea, Mascagni, Paolo, Dinarello, Charles A., Ferrara, James L.M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2008
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2430497/
https://ncbi.nlm.nih.gov/pubmed/18568076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34712
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