Interleukin-18, together with interleukin-12, induces severe acute pancreatitis in obese but not in nonobese leptin-deficient mice

Obesity is associated with increased severity of acute pancreatitis (AP). The cytokines IL-18 and IL-12 are elevated in patients with AP, and IL-18 levels are high in obesity. We aimed to develop a pathologically relevant model to study obesity-associated severe AP. Lean WT and obese leptin-deficien...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Sennello, Joseph A., Fayad, Raja, Pini, Maria, Gove, Melissa E., Ponemone, Venkatesh, Cabay, Robert J., Siegmund, Britta, Dinarello, Charles A., Fantuzzi, Giamila
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2008
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2430363/
https://ncbi.nlm.nih.gov/pubmed/18515422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804091105
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge