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Decoding of Superimposed Traces Produced by Direct Sequencing of Heterozygous Indels

Direct Sanger sequencing of a diploid template containing a heterozygous insertion or deletion results in a difficult-to-interpret mixed trace formed by two allelic traces superimposed onto each other. Existing computational methods for deconvolution of such traces require knowledge of a reference s...

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Hlavní autoři: Dmitriev, Dmitry A., Rakitov, Roman A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2429969/
https://ncbi.nlm.nih.gov/pubmed/18654614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000113
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