Btk dosage determines sensitivity to B cell antigen receptor cross-linking

Mutations in Btk result in the B cell immunodeficiencies X-linked agammaglobulinemia (XLA) in humans and X-linked immunodeficiency (xid) in mice. Btk is a critical component of signaling pathways regulating B cell development and function. We used a genetic approach to determine whether Btk is also...

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Bibliografiska uppgifter
Huvudupphovsmän: Satterthwaite, Anne B., Cheroutre, Hilde, Khan, Wasif N., Sideras, Pascalis, Witte, Owen N.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The National Academy of Sciences of the USA 1997
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC24278/
https://ncbi.nlm.nih.gov/pubmed/9371815
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