PKCβ modulates antigen receptor signaling via regulation of Btk membrane localization

Mutations in Bruton’s tyrosine kinase (Btk) result in X-linked agammaglobulinemia (XLA) in humans and X-linked immunodeficiency (xid) in mice. While targeted disruption of the protein kinase C-β (PKCβ) gene in mice results in an immunodeficiency similar to xid, the overall tyrosine phosphorylation o...

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Autori principali: Kang, Shin W., Wahl, Matthew I., Chu, Julia, Kitaura, Jiro, Kawakami, Yuko, Kato, Roberta M., Tabuchi, Ruby, Tarakhovsky, Alexander, Kawakami, Toshiaki, Turck, Christoph W., Witte, Owen N., Rawlings, David J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2001
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC125669/
https://ncbi.nlm.nih.gov/pubmed/11598012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.20.5692
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