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Leishmania Trypanothione Synthetase-Amidase Structure Reveals a Basis for Regulation of Conflicting Synthetic and Hydrolytic Activities

The bifunctional trypanothione synthetase-amidase catalyzes biosynthesis and hydrolysis of the glutathione-spermidine adduct trypanothione, the principal intracellular thiol-redox metabolite in parasitic trypanosomatids. These parasites are unique with regard to their reliance on trypanothione to de...

詳細記述

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書誌詳細
主要な著者: Fyfe, Paul K., Oza, Sandra L., Fairlamb, Alan H., Hunter, William N.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2427367/
https://ncbi.nlm.nih.gov/pubmed/18420578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801850200
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