Neogenin-mediated Hemojuvelin Shedding Occurs after Hemojuvelin Traffics to the Plasma Membrane

HFE2 (hemochromatosis type 2 gene) is highly expressed in skeletal muscle and liver hepatocytes. Its encoded protein, hemojuvelin (HJV), is a co-receptor for the bone morphogenetic proteins 2 and 4 (BMP2 and BMP4) and enhances the BMP-induced hepcidin expression. Hepcidin is a central iron regulator...

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Bibliographic Details
Main Authors: Zhang, An-Sheng, Yang, Fan, Meyer, Kathrin, Hernandez, Catalina, Chapman-Arvedson, Tara, Bjorkman, Pamela J., Enns, Caroline A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Molecular Basis of Cell and Developmental Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2427329/
https://ncbi.nlm.nih.gov/pubmed/18445598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M710527200
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