NDUFA2 Complex I Mutation Leads to Leigh Disease

Mitochondrial isolated complex I deficiency is the most frequently encountered OXPHOS defect. We report a patient with an isolated complex I deficiency expressed in skin fibroblasts as well as muscle tissue. Because the parents were consanguineous, we performed homozygosity mapping to identify homoz...

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Bibliografische gegevens
Hoofdauteurs: Hoefs, Saskia J.G., Dieteren, Cindy E.J., Distelmaier, Felix, Janssen, Rolf J.R.J., Epplen, Andrea, Swarts, Herman G.P., Forkink, Marleen, Rodenburg, Richard J., Nijtmans, Leo G., Willems, Peter H., Smeitink, Jan A.M., van den Heuvel, Lambert P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Human Genetics 2008
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2427319/
https://ncbi.nlm.nih.gov/pubmed/18513682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2008.05.007
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