Two CES1 Gene Mutations Lead to Dysfunctional Carboxylesterase 1 Activity in Man: Clinical Significance and Molecular Basis

The human carboxylesterase 1 (CES1) gene encodes for the enzyme carboxylesterase 1, a serine esterase governing both metabolic deactivation and activation of numerous therapeutic agents. During the course of a study of the pharmacokinetics of the methyl ester racemic psychostimulant methylphenidate,...

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Autors principals: Zhu, Hao-Jie, Patrick, Kennerly S., Yuan, Hong-Jie, Wang, Jun-Sheng, Donovan, Jennifer L., DeVane, C. Lindsay, Malcolm, Robert, Johnson, Julie A., Youngblood, Geri L., Sweet, Douglas H., Langaee, Taimour Y., Markowitz, John S.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Human Genetics 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2427248/
https://ncbi.nlm.nih.gov/pubmed/18485328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2008.04.015
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