CES1P1 variant −816A>C is not associated with hepatic carboxylesterase 1 expression, activity or antihypertensive effect of trandolapril

PURPOSE: The majority of angiotensin-converting enzyme inhibitors (ACEIs) are synthesized as ester prodrugs that must be converted to their active forms in vivo in order to exert therapeutic effects. Hepatic carboxylesterase 1 (CES1) is the primary enzyme responsible for the bioactivation of ACEI pr...

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Detalhes bibliográficos
Publicado no:Eur J Clin Pharmacol
Main Authors: Zhu, Hao-Jie, Langaee, Taimour Y., Gong, Yan, Wang, Xinwen, Pepine, Carl J., Cooper-DeHoff, Rhonda M., Johnson, Julie A., Markowitz, John S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865408/
https://ncbi.nlm.nih.gov/pubmed/26915813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-016-2029-x
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