Cytokine secretion requires phosphatidylcholine synthesis

Choline cytidylyltransferase (CCT) is the rate-limiting enzyme in the phosphatidylcholine biosynthetic pathway. Here, we demonstrate that CCTα-mediated phosphatidylcholine synthesis is required to maintain normal Golgi structure and function as well as cytokine secretion from the Golgi complex. CCTα...

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Detalhes bibliográficos
Main Authors: Tian, Yong, Pate, Caroline, Andreolotti, Alberto, Wang, Limin, Tuomanen, Elaine, Boyd, Kelli, Claro, Enrique, Jackowski, Suzanne
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2008
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2426940/
https://ncbi.nlm.nih.gov/pubmed/18559668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200706152
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