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Are Current Molecular Dynamics Force Fields too Helical?

Accurate force fields are essential for the success of molecular dynamics simulations. In apparent contrast to the conformational preferences of most force fields, recent NMR experiments suggest that short polyalanine peptides in water populate the polyproline II structure almost exclusively. To inv...

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Hlavní autoři: Best, Robert B., Buchete, Nicolae-Viorel, Hummer, Gerhard
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2426634/
https://ncbi.nlm.nih.gov/pubmed/18456823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.108.132696
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