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A role for Caf1 in mRNA deadenylation and decay in trypanosomes and human cells

The eukaryotic Ccr4/Caf1/Not complex is involved in deadenylation of mRNAs. The Caf1 and Ccr4 subunits both potentially have deadenylating enzyme activity. We investigate here the roles of Ccr4 and Caf1 in deadenylation in two organisms that separated early in eukaryotic evolution: humans and trypan...

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Hlavní autoři: Schwede, Angela, Ellis, Louise, Luther, Julia, Carrington, Mark, Stoecklin, Georg, Clayton, Christine
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2008
Témata:
RNA
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2425496/
https://ncbi.nlm.nih.gov/pubmed/18442996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn108
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