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Direct inhibition of the DNA-binding activity of POU transcription factors Pit-1 and Brn-3 by selective binding of a phenyl-furan-benzimidazole dication

The development of small molecules to control gene expression could be the spearhead of future-targeted therapeutic approaches in multiple pathologies. Among heterocyclic dications developed with this aim, a phenyl-furan-benzimidazole dication DB293 binds AT-rich sites as a monomer and 5′-ATGA seque...

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Detalhes bibliográficos
Main Authors: Peixoto, Paul, Liu, Yang, Depauw, Sabine, Hildebrand, Marie-Paule, Boykin, David W., Bailly, Christian, Wilson, W. David, David-Cordonnier, Marie-Hélène
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2425483/
https://ncbi.nlm.nih.gov/pubmed/18440973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn208
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