Keratinocyte growth factor and androgen blockade work in concert to protect against conditioning regimen-induced thymic epithelial damage and enhance T-cell reconstitution after murine bone marrow transplantation

Myeloablative conditioning results in thymic epithelial cell (TEC) injury, slow T-cell reconstitution, and a high risk of opportunistic infections. Keratinocyte growth factor (KGF) stimulates TEC proliferation and, when given preconditioning, reduces TEC injury. Thymocytes and TECs express androgen...

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Hlavní autoři: Kelly, Ryan M., Highfill, Steven L., Panoskaltsis-Mortari, Angela, Taylor, Patricia A., Boyd, Richard L., Holländer, Georg A., Blazar, Bruce R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2008
Témata:
Transplantation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2424165/
https://ncbi.nlm.nih.gov/pubmed/18334670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-01-136531
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