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Enhanced selenium effect on growth arrest by BiP/GRP78 knockdown in p53-null human prostate cancer cells
Redox modification of thiol/disulfide interchange in proteins by selenium could lead to protein unfolding. When this occurs in the endoplasmic reticulum (ER), a process known as unfolded protein response (UPR) is orchestrated for survival through activation of PERK–eIF2α(PERK: double-stranded RNA-ac...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2424019/ https://ncbi.nlm.nih.gov/pubmed/16205645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.onc.1209071 |
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