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Synthesis and inhibitory activity of oligosaccharide thiazolines as a class of mechanism-based inhibitors for endo-β-N-acetylglucosaminidases

A facile synthesis of oligosaccharide-thiazoline derivatives of N-glycans as a novel class of inhibitors for endo-β-N-acetylglucosaminidases was described. It was found that the external sugar residues on the N-glycan core could enhance the inhibitory potency. While the Manβ1,4GlcNAc- and Man3GlcNAc...

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Bibliografske podrobnosti
Main Authors: Li, Bing, Takegawa, Kaoru, Suzuki, Tadashi, Yamamoto, Kenji, Wang, Lai-Xi
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423928/
https://ncbi.nlm.nih.gov/pubmed/18304822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.02.032
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