Kcnq1ot1/Lit1 Noncoding RNA Mediates Transcriptional Silencing by Targeting to the Perinucleolar Region

The Kcnq1ot1 antisense noncoding RNA has been implicated in long-range bidirectional silencing, but the underlying mechanisms remain enigmatic. Here we characterize a domain at the 5′ end of the Kcnq1ot1 RNA that carries out transcriptional silencing of linked genes using an episomal vector system....

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Hlavní autoři: Mohammad, Faizaan, Pandey, Radha Raman, Nagano, Takashi, Chakalova, Lyubomira, Mondal, Tanmoy, Fraser, Peter, Kanduri, Chandrasekhar
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423283/
https://ncbi.nlm.nih.gov/pubmed/18299392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02263-07
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