Validity of Models for Predicting BRCA1 and BRCA2 Mutations

BACKGROUND: Deleterious mutations of the BRCA1 and BRCA2 genes confer susceptibility to breast and ovarian cancer. At least 7 models for estimating the probabilities of having a mutation are used widely in clinical and scientific activities; however, the merits and limitations of these models are no...

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Detalhes bibliográficos
Principais autores: Parmigiani, Giovanni, Chen, Sining, Iversen, Edwin S., Friebel, Tara M., Finkelstein, Dianne M., Anton-Culver, Hoda, Ziogas, Argyrios, Weber, Barbara L., Eisen, Andrea, Malone, Kathleen E., Daling, Janet R., Hsu, Li, Ostrander, Elaine A., Peterson, Leif E., Schildkraut, Joellen M., Isaacs, Claudine, Corio, Camille, Leondaridis, Leoni, Tomlinson, Gail, Amos, Christopher I., Strong, Louise C., Berry, Donald A., Weitzel, Jeffrey N., Sand, Sharon, Dutson, Debra, Kerber, Rich, Peshkin, Beth N., Euhus, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423214/
https://ncbi.nlm.nih.gov/pubmed/17909205
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