Cyclooxygenase-2 induction by adiponectin is regulated by a sphingosine kinase-1 dependent mechanism in cardiac myocytes

The adipose-derived plasma protein, adiponectin (APN), has various protective effects on cardiovascular diseases. In this study, we show that endogenous APN is required for full cyclooxygenase-2 (COX-2) induction by ischemia-reperfusion injury in the heart in vivo. In rat neonatal cardiac myocytes,...

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Autores principales: Ikeda, Yasumasa, Ohashi, Koji, Shibata, Rei, Pimentel, David R., Kihara, Shinji, Ouchi, Noriyuki, Walsh, Kenneth
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423200/
https://ncbi.nlm.nih.gov/pubmed/18339320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2008.03.002
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