Protection against Nasopharyngeal Colonization by Streptococcus pneumoniae Is Mediated by Antigen-Specific CD4(+) T Cells

CD4(+) T-cell-dependent acquired immunity confers antibody-independent protection against pneumococcal colonization. Since this mechanism is poorly understood for extracellular bacteria, we assessed the antigen specificity of the induction and recall of this immune response by using BALB/c DO11.10Ra...

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Main Authors: Trzciński, Krzysztof, Thompson, Claudette M., Srivastava, Amit, Basset, Alan, Malley, Richard, Lipsitch, Marc
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2008
Fag:
Host Response and Inflammation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423086/
https://ncbi.nlm.nih.gov/pubmed/18391006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00141-08
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