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Bcl-XL Inhibits Membrane Permeabilization by Competing with Bax
Although Bcl-XL and Bax are structurally similar, activated Bax forms large oligomers that permeabilize the outer mitochondrial membrane, thereby committing cells to apoptosis, whereas Bcl-XL inhibits this process. Two different models of Bcl-XL function have been proposed. In one, Bcl-XL binds to a...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2422857/ https://ncbi.nlm.nih.gov/pubmed/18547146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0060147 |
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