Truncated BRCA2 is cytoplasmic: Implications for cancer-linked mutations
BRCA2 mutations predispose carriers mainly to breast cancer. The vast majority of BRCA2 mutations are predicted to result in a truncated protein product. The smallest known cancer-associated deletion removes from the C terminus only 224 of the 3,418 residues constituting BRCA2, suggesting that these...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24166/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10570174/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.24.13920 |
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